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How DERAMAXX^® (deracoxib) Works to Control Pain.

DERAMAXX® is a coxib-class NSAID approved for use in veterinary medicine.*

DERAMAXX is a type of nonsteroidal anti-inflammatory drug (NSAID). Nonsteroidals are medicines that control the clinical signs of inflammation, including pain, redness, warmth and swelling. Common examples of NSAIDs that people use are aspirin, ibuprofen and naproxen (the active ingredients in many over-the-counter pain relievers).

Some NSAIDs, such as ibuprofen and naproxen, relieve pain and reduce inflammation by blocking the actions of both COX-1 and COX-2 enzymes. The COX-1 enzyme makes prostaglandins, chemicals necessary for many normal body functions, such as blood clotting, protection of the stomach lining and kidney function. COX-2 also makes prostaglandins, but most of these trigger inflammation and contribute to pain in arthritic joints. See Figure 1.

DERAMAXX is different from traditional NSAIDs because at recommended doses it blocks the COX-2 enzyme and not the COX-1 enzyme. The ability of DERAMAXX to select for COX-2 has been demonstrated scientifically in laboratory (in vitro) studies with cloned canine COX-1 and COX-2 enzymes. The clinical significance of these findings is unknown, but researchers are excited about these results.

As with all drugs in this class, side effects involving the digestive system, kidneys or liver may occur. These are normally mild, but may be serious. Pet owners should discontinue therapy and contact their veterinarian immediately if side effects occur. Evaluation for preexisting conditions and regular monitoring are recommended for pets on any medication, including DERAMAXX. Use with other NSAIDs or corticosteroids should be avoided.
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*NADA 141-203, approved by FDA.